- lentigines appear in more than 90% of patients - do not need to be present to diagnose the syndrome
- freckling around armpit region
- malformation of the nails
- webbing between fingers
- stretchy skin
Non-cutaneous
- _hearing loss in 25% of patients
- short stature
- mild degree of mental retardation
- craniofacial adnormalities
- heart abnormalities
- abnormalities of genitalia